Birdwatch Note
2024-10-29 08:47:24 UTC - MISINFORMED_OR_POTENTIALLY_MISLEADING
コスタイベはベネズエラ馬脳炎ウイルス(VEEV)の要素を含んでおり、VEEVは脳に侵入し、脳炎を起こすので、同様に脳炎を起こす可能性があるというブログの示唆はもっともらしく聞こえます。 しかし、コスタイベが含むVEEVの要素はRNAの複製を行うレプリカーゼのみです(36p)。 https://www.pmda.go.jp/drugs/2023/P20231122002/index.html VEEVが脳に侵入する分子機構は、レプリカーゼとは関係がなく、E1,E2等の様々なVEEVの持つ構造タンパクがかかわっています(下記の論文のintroに要約があります)。 https://www.cell.com/cell-reports/fulltext/S2211-1247(23)00957-9 そのため、上記のような推論は実際にはまるで、分子機構からみて意味を成していない事に注意が必要です。
Written by 41A6243EF0C5E2F69F5A0D4006A468F4F7CBEC237CAE6ACCC5FB56ED687492FE
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All Information
- ID - 1851184044802998342
- noteId - 1851184044802998342
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- noteAuthorParticipantId - 41A6243EF0C5E2F69F5A0D4006A468F4F7CBEC237CAE6ACCC5FB56ED687492FE Participant Details
- createdAtMillis - 1730191644274
- tweetId - 1851091643711275041
- classification - MISINFORMED_OR_POTENTIALLY_MISLEADING
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- summary
- コスタイベはベネズエラ馬脳炎ウイルス(VEEV)の要素を含んでおり、VEEVは脳に侵入し、脳炎を起こすので、同様に脳炎を起こす可能性があるというブログの示唆はもっともらしく聞こえます。 しかし、コスタイベが含むVEEVの要素はRNAの複製を行うレプリカーゼのみです(36p)。 https://www.pmda.go.jp/drugs/2023/P20231122002/index.html VEEVが脳に侵入する分子機構は、レプリカーゼとは関係がなく、E1,E2等の様々なVEEVの持つ構造タンパクがかかわっています(下記の論文のintroに要約があります)。 https://www.cell.com/cell-reports/fulltext/S2211-1247(23)00957-9 そのため、上記のような推論は実際にはまるで、分子機構からみて意味を成していない事に注意が必要です。
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